BDBM517126 N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide::US11104676, Example 196

SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc4[nH]nc(N)c34)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O

InChI Key InChIKey=QKQBOUUDOCRITG-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 517126   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  1.00E+3nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  1.05E+4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  2.20E+4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  2.60nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [1-13,15-1390](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  10.9nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230S](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  4.80nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228N](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  4.20nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [F1200I](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  5.70nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [L1195V](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  44.4nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230C](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  4.80nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [Y1230H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  7.90nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHepatocyte growth factor receptor [D1228H](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM517126(N-(4-((3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)...)
Affinity DataIC50:  7nMAssay Description:The affinity of compound binding to wild type and mutant human MET kinases is measured using Invitrogen's LanthaScreen™ Eu Kinase Binding technol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent