BDBM520580 (3R,6R,7S,8E,22S)-6′-Chloro-7-[2-[4-(2-methoxyethyl)-1,4-diazepan-1-yl]ethoxy]-11,12,12-trimethyl-15,15-dioxo-spiro[20-oxa-15-thia-1,11,14-triazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16,18,24-tetraene-22,1′-tetralin]-13-one::US11130769, Ex. No. 277

SMILES COCCN1CCCN(CCO[C@H]2\C=C\CN(C)C(C)(C)C(=O)NS(=O)(=O)c3ccc4OC[C@]5(CCCc6cc(Cl)ccc56)CN(C[C@@H]5CC[C@@H]25)c4c3)CC1

InChI Key InChIKey=FYDKHLAQJPJFTD-HENRWGRRSA-N

Data  1 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 520580   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Prelude Therapeutics

US Patent
LigandPNGBDBM520580((3R,6R,7S,8E,22S)-6′-Chloro-7-[2-[4-(2-metho...)
Affinity DataKi: <100nMAssay Description:The assay was carried out in black half-area 96-well NBS plate (Corning), containing 15 nM of MCL-1 (BPS Bioscience), 5 nM of FITC-Bim and 3-fold ser...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent