BDBM525560 5-(1-(6-(3-fluoro-4-(2- hydroxypropan-2- yl)pyrrolidin-1- yl)pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile, cis isomer 1::US11174248, Example 22::US11174248, Example 23
SMILES CC(C)(O)C1CN(CC1F)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N
InChI Key InChIKey=GUZWYTWSJZWQGF-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 525560
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 4.60nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 3.70nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair