BDBM525560 5-(1-(6-(3-fluoro-4-(2- hydroxypropan-2- yl)pyrrolidin-1- yl)pyrimidin-4-yl)-1H- indazol-6- yl)spiro[2.3]hexane-5- carbonitrile, cis isomer 1::US11174248, Example 22::US11174248, Example 23

SMILES CC(C)(O)C1CN(CC1F)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC2(CC2)C1)C#N

InChI Key InChIKey=GUZWYTWSJZWQGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 525560   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525560(5-(1-(6-(3-fluoro-4-(2- hydroxypropan-2- yl)pyrrol...)
Affinity DataIC50:  4.60nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM525560(5-(1-(6-(3-fluoro-4-(2- hydroxypropan-2- yl)pyrrol...)
Affinity DataIC50:  3.70nMAssay Description: Assays were performed in the presence of 134 μM ATP (Km ATP). Upon completion, the assay was stopped and phosphorylated substrate detected with...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent