BDBM527817 (2S,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 2-ol::US11179397, Example 34
SMILES Cc1nc(N2CCC3(C[C@H](O)C[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl
InChI Key InChIKey=BZDKBQKLCNDBHK-RHSMWYFYSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 527817
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 3.30nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair