BDBM527817 (2S,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- methylimidazo[1,2- c]pyrimidin-5-yl)-8- azaspiro[4.5]decan- 2-ol::US11179397, Example 34

SMILES Cc1nc(N2CCC3(C[C@H](O)C[C@H]3N)CC2)n2ccnc2c1-c1cccc(Cl)c1Cl

InChI Key InChIKey=BZDKBQKLCNDBHK-RHSMWYFYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527817   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM527817((2S,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- met...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent