BDBM527879 7-((5-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspiro[4.5]decan- 8-yl)imidazo[1,2- c]pyrimidin-8- yl)thio)benzo[b] thiophene-3- carbaldehyde::US11179397, Example 96

SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3cccc4c(C=O)csc34)c3nccn23)[C@@H]1N

InChI Key InChIKey=UPBAYCUREGCSOA-YCRPNKLZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527879   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM527879(7-((5-((3S,4S)-4- amino-3-methyl-2- oxa-8- azaspir...)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent