BDBM527920 (S)-1'-(8- (thieno[3,2- b]pyridin-7- ylthio)imidazo[1, 2-c]pyrimidin-5- yl)-1,3- dihydrospiro[indene- 2,4'- piperidin]-1- amine::US11179397, Example 139

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(Sc2ccnc3ccsc23)c2nccn12

InChI Key InChIKey=RWACCVNAMOXKCP-HSZRJFAPSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527920   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM527920((S)-1'-(8- (thieno[3,2- b]pyridin-7- ylthio)imidaz...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent