BDBM527920 (S)-1'-(8- (thieno[3,2- b]pyridin-7- ylthio)imidazo[1, 2-c]pyrimidin-5- yl)-1,3- dihydrospiro[indene- 2,4'- piperidin]-1- amine::US11179397, Example 139
SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1ncc(Sc2ccnc3ccsc23)c2nccn12
InChI Key InChIKey=RWACCVNAMOXKCP-HSZRJFAPSA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 527920
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences
US Patent
Gilead Sciences
US Patent
Affinity DataIC50: 1.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair