BDBM527923 (S)-1'-(8-((2- (ethylthio)phenyl) thio)imidazo[1,2-c] pyrimidin-5- yl)-1,3- dihydrospiro [indene-2,4'- piperidin]-1- amine::US11179397, Example 142

SMILES CCSc1ccccc1Sc1cnc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)n2ccnc12

InChI Key InChIKey=UQWFEWOXHJBXTG-XMMPIXPASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 527923   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM527923((S)-1'-(8-((2- (ethylthio)phenyl) thio)imidazo[1,2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent