BDBM530432 7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-imidazol-4-yl)-4-isopropyl-2- (o-tolyl)isoquinolin-1(2H)-one.::WO2022070068, Example 23::WO2022070068, Example 4

SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1cn(C)c(n1)C(C)(C)O

InChI Key InChIKey=GWMXFXJODPDSNG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 530432   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Biotech

WIPO
LigandPNGBDBM530432(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Affinity DataIC50:  0.540nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Biotech

WIPO
LigandPNGBDBM530432(7-Fluoro-6-(2-(2-hydroxypropan-2-yl)-1-methyl-1H-i...)
Affinity DataIC50:  0.380nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed