BDBM530452 6-(5-Acetyl-1-ethyl-1H-1,2,4-triazol-3-yl)-7-fluoro-4-isopropyl-2-(o-tolyl)isoquinolin-1(2H)-one.::WO2022070068, Example 24

SMILES CCn1nc(nc1C(C)=O)-c1cc2c(cn(-c3ccccc3C)c(=O)c2cc1F)C(C)C

InChI Key InChIKey=OXLSSZJIPPYXRV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 530452   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Biotech

WIPO
LigandPNGBDBM530452(6-(5-Acetyl-1-ethyl-1H-1,2,4-triazol-3-yl)-7-fluor...)
Affinity DataIC50:  6.20nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed