BDBM531022 (R)-4-(2-oxopiperidin-1-yl)-N1- (pyrrolidin-3-yl)-3-(2H-tetrazol- 5-yl)benzene-1,2-disulfonamide::US11207312, Example 154

SMILES NS(=O)(=O)c1c(ccc(N2CCCCC2=O)c1-c1nn[nH]n1)S(=O)(=O)N[C@@H]1CCNC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531022   

TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531022((R)-4-(2-oxopiperidin-1-yl)-N1- (pyrrolidin-3-yl)-...)
Affinity DataIC50:  0.350nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531022((R)-4-(2-oxopiperidin-1-yl)-N1- (pyrrolidin-3-yl)-...)
Affinity DataIC50:  0.730nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531022((R)-4-(2-oxopiperidin-1-yl)-N1- (pyrrolidin-3-yl)-...)
Affinity DataIC50:  0.260nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531022((R)-4-(2-oxopiperidin-1-yl)-N1- (pyrrolidin-3-yl)-...)
Affinity DataIC50:  8.46nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent