BDBM531032 Methyl 1-(4-(N-((R)- pyrrolidin-3-yl)sulfamoyl)-3- sulfamoyl-2-(2H-tetrazol-5- yl)phenyl)-1,4-diazepane-5- carboxylate hydrochloride::US11207312, Example 164

SMILES COC(=O)C1CCN(CCN1)c1ccc(c(c1-c1nn[nH]n1)S(N)(=O)=O)S(=O)(=O)N[C@@H]1CCNC1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 531032   

TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531032(Methyl 1-(4-(N-((R)- pyrrolidin-3-yl)sulfamoyl)-3-...)
Affinity DataIC50:  0.630nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase VIM-2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531032(Methyl 1-(4-(N-((R)- pyrrolidin-3-yl)sulfamoyl)-3-...)
Affinity DataIC50:  0.690nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531032(Methyl 1-(4-(N-((R)- pyrrolidin-3-yl)sulfamoyl)-3-...)
Affinity DataIC50:  0.120nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM531032(Methyl 1-(4-(N-((R)- pyrrolidin-3-yl)sulfamoyl)-3-...)
Affinity DataIC50:  0.540nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent