BDBM531360 (3S,5R)-5-((6-(2-Hydroxy-6-methyl-4-(trifluoromethyl)phenyl)pyridazin-3-yl)amino)-1-methylpiperidin-3-ol::US11208399, Example 97

SMILES CN1C[C@@H](O)C[C@H](C1)NC1=N[H]=C(C=C1)c1c(C)cc(cc1O)C(F)(F)F

InChI Key InChIKey=UVYYFXLFBKDDGW-OLZOCXBDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 531360   

TargetTumor necrosis factor(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531360((3S,5R)-5-((6-(2-Hydroxy-6-methyl-4-(trifluorometh...)
Affinity DataIC50: >1.00E+5nMAssay Description:Monocytic THP-1 cells were maintained according to providers' instructions in RPMI media as described above. Undifferentiated cells were plated a...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetInterleukin-1 beta(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM531360((3S,5R)-5-((6-(2-Hydroxy-6-methyl-4-(trifluorometh...)
Affinity DataIC50:  7.60nMAssay Description:Monocytic THP-1 cells (ATCC: TIB-202) were maintained according to providers' instructions in RPMI media (RPMI/Hepes+10% fetal bovine serum+Sodiu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent