BDBM562227 1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7,8,9-tetrahydro-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one::US11401274, Example 1

SMILES CCCn1c2CCCCc2n2c(nnc2c1=O)C1(CC1)C1CC1

InChI Key InChIKey=ZOYWVKURDMXZTC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 562227   

LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50:  2.90nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50:  3.10nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha/beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50: >1.00E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50: >1.00E+5nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50:  1.27E+4nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM562227(1-([1,1′-bi(cyclopropan)]-1-yl)-5-propyl-6,7...)
Affinity DataIC50:  3.30nMAssay Description:All 3′, 5′ cyclic nucleotide phosphodiesterase (PDE) enzyme activities are measured with a radiometric enzyme assay based on SPA detectio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent