BDBM5710 (3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-1-benzopyran-4-one::2-[(2-chlorophenyl)sulfanyl]-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::Flavopiridol analogue 16

SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(Sc1ccccc1Cl)cc2=O

InChI Key InChIKey=KMOIDYHHPHGHBT-MEDUHNTESA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 5710   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  110nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  2.10E+3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  1.62E+4nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of human GST-tagged CDK4/cyclin D1 expressed in baculovirus after 1 hr in presence of [gamma-33P]ATP by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  1.62E+4nMAssay Description:Inhibition of GST-tagged human CDK4 expressed in baculovirus expression system using GST-RB fusion protein as substrate incubated for 1 hr in presenc...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human GST-tagged CDK1/cyclin B1 expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  110nMAssay Description:Inhibition of GST-tagged human CDK1 expressed in baculovirus expression system using histone H1 as substrate incubated for 45 mins in presence of [ga...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Hefei University Of Technology

Curated by ChEMBL
LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of GST-tagged human CDK2 expressed in baculovirus expression system using GST-RB fusion protein as substrate incubated for 45 mins in pres...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5710((3S,4R)-2-[(2-Chlorophenyl)thio]-5,7-dihydroxy-8-(...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human GST-tagged CDK2/cyclinE expressed in baculovirus after 45 mins in presence of [gamma-33P]ATP by liquid scintillation counting ana...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed