BDBM5713 (+/-)-(3SR,4RS)-2-(Phenylthio)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-1-benzopyran-4-one::5,7-dihydroxy-8-(3-hydroxy-1-methylpiperidin-4-yl)-2-(phenylsulfanyl)-4H-chromen-4-one::CHEMBL112050::Flavopiridol analogue 22

SMILES CN1CCC(C(O)C1)c1c(O)cc(O)c2c1oc(Sc1ccccc1)cc2=O

InChI Key InChIKey=FRPNTLUZPVREQA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5713   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5713((+/-)-(3SR,4RS)-2-(Phenylthio)-5,7-dihydroxy-8-(3-...)
Affinity DataIC50:  440nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM5713((+/-)-(3SR,4RS)-2-(Phenylthio)-5,7-dihydroxy-8-(3-...)
Affinity DataIC50:  6.59E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2 (CDK2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5713((+/-)-(3SR,4RS)-2-(Phenylthio)-5,7-dihydroxy-8-(3-...)
Affinity DataIC50:  4.10E+3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM5713((+/-)-(3SR,4RS)-2-(Phenylthio)-5,7-dihydroxy-8-(3-...)
Affinity DataIC50:  6.59E+3nMAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed