BDBM573484 US11453683, Example 340::US20230279025, Example 340
SMILES Oc1ccc(OC(F)(F)F)c(c1)-c1ncc2c(nc(OCC34CCCN3C[C@H](F)C4)nc2c1F)N1CC2CCC(C1)N2
InChI Key InChIKey=UTPRGICGUZDDSL-BXTZJHJISA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 573484
Affinity DataIC50: 0.400nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 51.5nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair