BDBM573647 US11453683, Example 441::US20230279025, Example 441
SMILES CCc1c(F)ccc2cc(O)cc(-c3ncc4c(nc(OC[C@]56CCCN5[C@@H](COC(=O)N(C)C)CC6)nc4c3F)N3CC4CCC(C3)N4)c12
InChI Key InChIKey=UJSHZDYXVXMKFX-DWJPXOSPSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 573647
Affinity DataIC50: 0.5nMAssay Description:This Example illustrates that exemplary compounds of the present invention inhibit the phosphorylation of ERK downstream of KRAS G12D. AGS cells (ATC...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Table 2: The ability of a compound to bind to KRAS G12D was measured using a TR-FRET displacement assay. Biotinylated GDP-loaded recombinant human KR...More data for this Ligand-Target Pair