BDBM575988 US11466016, Example 122::{3- [(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabicyclo[3.2.1]oc- tan-8-yl]-7-(3,4- dichloro-2-methyl- 2H-indazol-5-yl)- 5H-pyrrolo[2,3- b]pyrazin-2- yl}methanol
SMILES Cn1nc2ccc(-c3c[nH]c4nc(N5[C@H]6CC[C@@H]5[C@@H](F)[C@@H](N)C6)c(CO)nc34)c(Cl)c2c1Cl
InChI Key
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 575988
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical
US Patent
Otsuka Pharmaceutical
US Patent
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair