BDBM575997 US11466016, Example 131::{6-[endo-3-amino-3- methyl-8- azabicyclo[3.2.1] octan-8-yl]- 3-[5-chloro-3- (dimethylamino) quinoxalin- 6-yl]-1H- pyrazolo[3,4- b]pyrazin-5- yl}methanol
SMILES CN(C)c1cnc2ccc(-c3n[nH]c4nc(N5[C@H]6CC[C@@H]5C[C@@](C)(N)C6)c(CO)nc34)c(Cl)c2n1
InChI Key
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 575997
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Otsuka Pharmaceutical
US Patent
Otsuka Pharmaceutical
US Patent
Affinity DataIC50: 8.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair