BDBM576396 4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole::WO2022112919, Example 1

SMILES Cc1n[nH]c(C)c1-c1cccc2scnc12

InChI Key InChIKey=YFMRWZLTMDNCMD-UHFFFAOYSA-N

Data  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576396   

TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576396(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataKd:  39nMAssay Description:Affinity and Reversibility -The binding affinity and kinetics of binding were measured using Surface Plasmon Resonance based binding assay. These exp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTransthyretin(Homo sapiens (Human))
Pfizer

WIPO
LigandPNGBDBM576396(4-(3,5-dimethyl-1H-pyrazol-4-yl)-1,3-benzothiazole...)
Affinity DataEC50:  31nMAssay Description:TTR SPA binding assays were performed in a final volume of 60 mI containing 100 ng human TTR (biotinylated recombinant protein) coupled to 25 pg SPA ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed