BDBM577015 3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol-3- yl)-1-isopropyl-1H- pyrazolo[4,3-c]pyridin-4- amine::US11472802, Example 25

SMILES CC(C)n1nc(-c2noc(C3CC3)c2-c2cc(C)ccn2)c2c(N)nccc12

InChI Key InChIKey=BHSFWTSRMMTMGN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 577015   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50:  0.800nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50:  3.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810S](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50:  3.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50:  7.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM577015(3-(5-cyclopropyl-4-(4- methylpyridin-2-yl)isoxazol...)
Affinity DataIC50:  0.800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent