BDBM578961 2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin- 6-yl)pyridin-3-yl)-5-chlorobenzonitrile;::US11479551, Example 8-4::US11492351, Example 8-4

SMILES NCc1n[nH]c(=O)c2ccc(cc12)-c1cncc(c1)-c1ccc(Cl)cc1C#N

InChI Key InChIKey=QVIQNFYEKFSULJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 578961   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578961(2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-...)
Affinity DataIC50:  3.10nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578961(2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-...)
Affinity DataIC50:  313nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578961(2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-...)
Affinity DataIC50:  3.10nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578961(2-(5-(4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-...)
Affinity DataIC50:  313nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent