BDBM597669 5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoropropan- 2-yl)-7H-pyrrolo[2,3- d]pyrimidin-4-amine::US11603374, Example 24

SMILES CC(n1cc(-c2cc(on2)C2CC2)c2c(N)ncnc12)C(F)(F)F

InChI Key InChIKey=XNTVLBKDSVFJDB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 597669   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50:  1.30nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50:  2.5nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810S](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50:  3.10nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [G810R](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50:  4.20nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [M918T](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM597669(5-(5-cyclopropylisoxazol-3- yl)-7-(1,1,1-trifluoro...)
Affinity DataIC50:  0.800nMAssay Description:The potency of compounds inhibiting several different RET kinase forms (Wild Type, V804M, M918T, G810R, & G810S) were determined using CisBio's H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent