BDBM619933 N-[2-[2-[(3S,8aR)-7-[3-Chloro-2-fluoro-6-(tetrazol-1-yl)phenyl]-5-oxo-2,3,8,8a-tetrahydro-1H-indolizin-3-yl]-1H-imidazol-4-yl]-4-methoxy-phenyl]cyclopropanecarboxamide::US20230295157, Example 257

SMILES COc1ccc(NC(=O)C2CC2)c(c1)-c1c[nH]c(n1)[C@@H]1CC[C@@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 619933   

TargetKallikrein-1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619933(N-[2-[2-[(3S,8aR)-7-[3-Chloro-2-fluoro-6-(tetrazol...)
Affinity DataIC50:  0.700nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM619933(N-[2-[2-[(3S,8aR)-7-[3-Chloro-2-fluoro-6-(tetrazol...)
Affinity DataIC50:  0.5nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent