BDBM626317 2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran-5- yl]amino]methyl]prop-2-enamide::US11787775, Compound 2

SMILES CC(C)c1ccc(cc1)-c1cc(NCC(=C)C(N)=O)cc2CCOc12

InChI Key InChIKey=HVUUZUONXZOUQH-UHFFFAOYSA-N

Data  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 626317   

TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataIC50:  590nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-4(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataIC50:  80nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-5(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataIC50:  1.80E+4nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  90nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  460nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataEC50:  1.80E+4nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-3(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626317(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataIC50:  30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent