BDBM633360 US20190276450, Example 25
SMILES COCCOc1cc(nc(c1)[C@@]1(CCOC1)OC)-c1cn(C)c2cnc(NC(C)=O)cc12
InChI Key InChIKey=RFFXZSGAQDJMGT-QHCPKHFHSA-N
Data 3 EC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 633360
Affinity DataEC50: 25nMAssay Description:IL-12 is known to transduce its signal through IL-12 receptor via Jak2 and/or Tyk2. For that reason, the activity against Tyk2/Jak2 was measured by d...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Erythropoietin (EPO) is known to transduce its signal through EPO receptor via Jak2. Activity against Jak2 was therefore measured by determining inhi...More data for this Ligand-Target Pair
Affinity DataEC50: 4.90E+4nMAssay Description:IL-6 is known to transduce its signal through IL-6 receptor via Jak1. Activity against Jak was therefore measured by determining inhibition of IL-6 i...More data for this Ligand-Target Pair