BDBM6383 8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-phenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one::8-cyclopentyl-6-iodo-5-methyl-2-{[4-(piperazin-1-yl)phenyl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::pyrido[2,3-d]pyrimidin-7-one 30

SMILES Cc1c(I)c(=O)n(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc12

InChI Key InChIKey=XUPHGISRHZLRHR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 6383   

LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50:  5nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50:  1.87E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50: >360nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50:  365nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Institute Of Radiopharmacy

Curated by ChEMBL
LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50: >360nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM6383(8-Cyclopentyl-6-iodo-5-methyl-2-(4-piperazin-1-yl-...)
Affinity DataIC50:  443nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed