BDBM646606 6-bromo-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- pyrimidin-2-yl]-1H- pyrrolo[2,3-b]pyridine-3- sulfonamide::US20240025883, Example 111::US20240025883, Example 288

SMILES COc1nc(NS(=O)(=O)c2c[nH]c3nc(Br)ccc23)nc(OC)c1CC(F)CF

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 646606   

TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM646606(6-bromo-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- p...)
Affinity DataIC50:  57nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM646606(6-bromo-N-[5-(2,2- difluoroethyl)-4,6-dimethoxy- p...)
Affinity DataIC50:  13nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent