BDBM646747 N-[5-(2-cyanoethyl)-4,6- dimethoxy-pyrimidin-2-yl]-6- (difluoromethyl)-7-fluoro-1H- indole-3-sulfonamide::US20240025883, Example 252::US20240025883, Example 253

SMILES COc1nc(NS(=O)(=O)c2c[nH]c3c(F)c(ccc23)C(F)F)nc(OC)c1CCC#N

InChI Key InChIKey=RSYUGWUOHOLUST-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 646747   

TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM646747(N-[5-(2-cyanoethyl)-4,6- dimethoxy-pyrimidin-2-yl]...)
Affinity DataIC50:  20nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUracil nucleotide/cysteinyl leukotriene receptor(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM646747(N-[5-(2-cyanoethyl)-4,6- dimethoxy-pyrimidin-2-yl]...)
Affinity DataIC50:  14nMAssay Description:GPR17 cAMP Assay Protocol: CHO-K1 cells stably expressing vector containing untagged human GPR17 short isoform (Roche) were cultured at 37° C./5% CO2...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent