BDBM7979 (3S,4S)-5-[(4-bromophenyl)methoxy]-N-(cyclohexylmethyl)-3-hydroxy-4-[(2S)-3-methyl-2-(pyridin-2-ylformamido)butanamido]pentanamide::Statine-like inhibitor 18

SMILES CC(C)[C@H](NC(=O)c1ccccn1)C(=O)N[C@@H](COCc1ccc(Br)cc1)[C@@H](O)CC(=O)NCC1CCCCC1

InChI Key InChIKey=YTTGAYVPYPQRFA-NSVAZKTRSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7979   

TargetPlasmepsin I(Plasmodium falciparum)
Linkoping University

LigandPNGBDBM7979((3S,4S)-5-[(4-bromophenyl)methoxy]-N-(cyclohexylme...)
Affinity DataKi:  3.90nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasmepsin II(Plasmodium falciparum)
Linkoping University

LigandPNGBDBM7979((3S,4S)-5-[(4-bromophenyl)methoxy]-N-(cyclohexylme...)
Affinity DataKi:  41nM ΔG°:  -9.97kcal/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Linkoping University

LigandPNGBDBM7979((3S,4S)-5-[(4-bromophenyl)methoxy]-N-(cyclohexylme...)
Affinity DataKi:  586nMAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed