BDBM8053 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol::4-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]phenol, 5::4-{[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]amino}phenol::CHEMBL442957

SMILES Cc1nc(C)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1

InChI Key InChIKey=GDZTURHUKDAJGD-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8053   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataKi:  140nM ΔG°:  -9.50kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Cyclacel

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataKi:  320nM ΔG°:  -9.00kcal/moleT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Cambridge

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataIC50:  5.00E+3nMpH: 7.5 T: 2°CAssay Description:D. melanogaster Polo kinase assays were performed as previously described40, using baculovirus-expressed Polo kinase. Enzyme was immunoprecipitated u...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
University of Cambridge

LigandPNGBDBM8053(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 24 | 4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed