BDBM8143 N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine::pyrazolo[1,5-b]pyridazine deriv. 34

SMILES FC(F)(F)c1cc(Br)cc(Nc2nccc(n2)-c2cnn3ncccc23)c1

InChI Key InChIKey=LVHOFIUXRMSCFN-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 8143   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)
Affinity DataKi:  0.300nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)
Affinity DataIC50:  251nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)
Affinity DataIC50:  12nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed