BDBM81912 DC23::Resorcinol analog, 1

SMILES Oc1ccc(-c2n[nH]c(=S)n2-c2cccc3ccccc23)c(O)c1

InChI Key InChIKey=ISNBTODJGDBLAZ-UHFFFAOYSA-N

Data  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 81912   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  3.82E+3nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha [1-236](Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataKd:  25nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataKd:  6.76E+3nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University of Texas Southwestern Medical Center

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  280nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed