BDBM8575 4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20::N-{6-phenylfuro[2,3-d]pyrimidin-4-yl}cyclopentanecarboxamide

SMILES O=C(Nc1ncnc2oc(cc12)-c1ccccc1)C1CCCC1

InChI Key InChIKey=NJTNOAYYSGUBCP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 8575   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8575(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8575(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Protein kinase C beta 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8575(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Affinity DataIC50: >1.90E+4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence 1.4 uM ATP/[gamma-32P] ATP. A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Tsukuba Research Laboratories

LigandPNGBDBM8575(4-Acylamino-6-arylfuro[2,3-d]pyrimidine 20 | N-{6-...)
Affinity DataIC50: >2.30E+4nMAssay Description:The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed