BDBM88008 US10245267, Example 1043::US10709712, Example 1043::US9694016, 1043

SMILES Cc1ncc(NC(=O)c2ccnc(c2)S(C)(=O)=O)cc1-c1cc(NCCO)nc(c1)N1CCOCC1

InChI Key InChIKey=KRAKJGFWCBETHP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 88008   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM88008(US10245267, Example 1043 | US10709712, Example 104...)
Affinity DataIC50:  3.71nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM88008(US10245267, Example 1043 | US10709712, Example 104...)
Affinity DataIC50:  22.8nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails US Patent