BDBM92526 Aminopyrazole inhibitor, 4326

SMILES Cc1cncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c1

InChI Key InChIKey=KVVQUXAGSWSMKF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 92526   

TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM92526(Aminopyrazole inhibitor, 4326)
Affinity DataIC50:  55nMpH: 7.0 T: 2°CAssay Description:Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM92526(Aminopyrazole inhibitor, 4326)
Affinity DataIC50:  1.40E+3nMpH: 7.0 T: 2°CAssay Description:Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM92526(Aminopyrazole inhibitor, 4326)
Affinity DataIC50:  2.17E+3nMAssay Description:Inhibition of JNK1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM92526(Aminopyrazole inhibitor, 4326)
Affinity DataIC50:  117nMAssay Description:Inhibition of JNK3alpha1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM92526(Aminopyrazole inhibitor, 4326)
Affinity DataIC50: >2.00E+4nMpH: 7.0 T: 2°CAssay Description:Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed