BDBM97518 Roche-Dataset for PDE10A, Compound 5::US8470820, 29

SMILES O=C(Nc1cc(nn1Cc1ccccc1)-c1ccccn1)c1nc(ccc1Nc1cncnc1)C1CC1

InChI Key InChIKey=NZINDIRSIIELKH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 97518   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM97518(Roche-Dataset for PDE10A, Compound 5 | US8470820, ...)
Affinity DataIC50:  1.71nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM97518(Roche-Dataset for PDE10A, Compound 5 | US8470820, ...)
Affinity DataIC50:  2nMpH: 7.5Assay Description:Scintillation proximity assay using human PDE10A.More data for this Ligand-Target Pair
In DepthDetails US Patent