BDBM9920 (S)Fadrozole::4-[(5S)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile::4-[(5S)-5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl]benzonitrile::CHEMBL31215

SMILES N#Cc1ccc(cc1)[C@@H]1CCCc2cncn12

InChI Key InChIKey=CLPFFLWZZBQMAO-AWEZNQCLSA-N

Data  7 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 9920   

TargetAromatase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM9920((S)Fadrozole | 4-[(5S)-5,6,7,8-tetrahydroimidazo[1...)
Affinity DataIC50:  17nMpH: 7.4 T: 2°CAssay Description:The enzyme activity was assayed by measuring the 3H-labeled H2O formed from [1beta,2beta-3H]testosterone during aromatization. After incubation, the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM9920((S)Fadrozole | 4-[(5S)-5,6,7,8-tetrahydroimidazo[1...)
Affinity DatapH: 7.4 T: 2°CAssay Description:The 17 alpha-hydroxylase activity of CYP 17 was determined by measuring the conversion of progesterone into 17 alpha-hydroxyprogesterone and the bypr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed