BDBM99559 CHEMBL2062808::US8501936, 57

SMILES CS(=O)(=O)c1ccc(cc1)-c1cccn2nc(Nc3cccc(c3)N3CCC(CC3)N3CCOCC3)nc12

InChI Key InChIKey=GYQHHRDRGBGZKH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 99559   

TargetFocal adhesion kinase 1(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  1.18E+3nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  47.6nMAssay Description:The ability of compounds to inhibit the kinase activity of baculovirus-expressed human FAK and JAK kinase using the time-resolved fluorescence (TRF) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  89nMAssay Description:Inhibition of JAK2 in human TF-1 cells using GM-CSF pretreated for 1 hr prior to GM-CSF addition measured after 5 hrs by FRET based GeneBLAzer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human JAK2 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Cephalon

US Patent
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  60nMAssay Description:Inhibition of human JAK3 expressed in baculovirus using biotinyl-amino-hexanoyl-EQEDEPEGDYFEWLE-amide as substrate preincubated for 1 hr measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM99559(CHEMBL2062808 | US8501936, 57)
Affinity DataIC50:  200nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed