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Found 150 with Last Name = 'stammers' and Initial = 'dk'
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.0210nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026300(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026300(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0240nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026308(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0350nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026308(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0350nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026318(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026318(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026314(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0660nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026314(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.0660nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026307(3-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026307(3-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.370nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026317(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026317(4-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.470nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026316(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026316(5-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026306(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity against Dihydrofolate reductase Inhibitor of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026306(6-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  0.860nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026304(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026304(7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimeth...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026313(5-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026309(4-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026302(CHEMBL14201 | [5-(2,4-Diamino-pyrimidin-5-ylmethyl...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026302(CHEMBL14201 | [5-(2,4-Diamino-pyrimidin-5-ylmethyl...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026305(CHEMBL322001 | [4-(2,4-Diamino-pyrimidin-5-ylmethy...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026310(6-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026301(5-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026311(4-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimeth...)
Affinity DataKi:  5.20nMAssay Description:Relative Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50367239(CHEMBL318078)
Affinity DataKi:  9.80nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026315(CHEMBL266611 | [5-(2,4-Diamino-pyrimidin-5-ylmethy...)
Affinity DataKi:  11nMAssay Description:Binding affinity against Dihydrofolate reductase Inhibitor of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50026315(CHEMBL266611 | [5-(2,4-Diamino-pyrimidin-5-ylmethy...)
Affinity DataKi:  11nMAssay Description:Binding affinity for E. coli Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM50367240(CHEMBL104675)
Affinity DataKi:  16nMAssay Description:Binding affinity against Dihydrofolate reductase of Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)
Affinity DataIC50:  3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)
Affinity DataIC50:  5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Oxford University

Curated by ChEMBL
LigandPNGBDBM50050533(6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL | 6-...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity of the compound against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1802(2-Amino-6-arylthiobenzonitrile deriv. 3v, 739W94 |...)
Affinity DataIC50:  7nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Oxford University

Curated by ChEMBL
LigandPNGBDBM2337(6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity of the compound against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1805(2-Amino-6-arylthiobenzonitrile deriv. 3y | 2-amino...)
Affinity DataIC50:  10nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1801(2-Amino-6-arylthiobenzonitrile deriv. 3u | 2-amino...)
Affinity DataIC50:  30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1778(2-Amino-6-arylthiobenzonitrile deriv. 3ff | 2-amin...)
Affinity DataIC50:  30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1806(2-Amino-6-arylthiobenzonitrile deriv. 3z | 2-amino...)
Affinity DataIC50:  40nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1751(2-Amino-6-arylthiobenzonitrile deriv. 1u | 2-amino...)
Affinity DataIC50:  120nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1753(2-Amino-6-arylthiobenzonitrile deriv. 1w | 2-amino...)
Affinity DataIC50:  140nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1792(2-Amino-6-arylthiobenzonitrile deriv. 3l | 2-amino...)
Affinity DataIC50:  200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1786(2-Amino-6-arylthiobenzonitrile deriv. 3f | 2-amino...)
Affinity DataIC50:  200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1800(2-Amino-6-arylthiobenzonitrile deriv. 3t | 2-amino...)
Affinity DataIC50:  300nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1789(2-Amino-6-arylthiobenzonitrile deriv. 3i | 2-amino...)
Affinity DataIC50:  400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1776(2-Amino-6-arylthiobenzonitrile deriv. 3dd | 2-amin...)
Affinity DataIC50:  400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM1769(2-Amino-6-arylthiobenzonitrile deriv. 2n | 2-amino...)
Affinity DataIC50:  500nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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