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Found 262 with Last Name = 'nishimoto' and Initial = 'm'
TargetCytochrome P450 4A4(Oryctolagus cuniculus)
University of California

Curated by ChEMBL
LigandPNGBDBM50047304(12-Hydroxy-heptadec-16-ynoic acid | CHEMBL33390)
Affinity DataKi:  1.80E+3nMAssay Description:Inactivation of prostaglandin E1 omega-hydroxylase (Cytochrome P450 4A4) in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4A4(Oryctolagus cuniculus)
University of California

Curated by ChEMBL
LigandPNGBDBM50047307(12-Hydroxy-heptadec-16-ynoic acid | CHEMBL33875)
Affinity DataKi:  3.60E+3nMAssay Description:Inactivation of prostaglandin E1 omega-hydroxylase (Cytochrome P450 4A4) in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4A4(Oryctolagus cuniculus)
University of California

Curated by ChEMBL
LigandPNGBDBM50047305(12-Hydroxy-heptadec-16-ynoic acid | CHEMBL29370)
Affinity DataKi:  4.80E+3nMAssay Description:Inactivation of prostaglandin E1 omega-hydroxylase (Cytochrome P450 4A4) in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 4A4(Oryctolagus cuniculus)
University of California

Curated by ChEMBL
LigandPNGBDBM50047306(12-Hydroxy-2,2-dimethyl-heptadec-16-ynoic acid | C...)
Affinity DataKi:  4.90E+3nMAssay Description:Inactivation of prostaglandin E1 omega-hydroxylase (Cytochrome P450 4A4) in rabbit lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50303243((1S,3'R,4'S,5'S,6'R)-5-chloro-6-(4-ethylbenzyl)-6'...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396768(CHEMBL2172386)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396767(CHEMBL2172387)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396776(CHEMBL2172494)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396779(TOFOGLIFLOZIN)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396777(CHEMBL2172493)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396769(CHEMBL2172385)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396780(CHEMBL2172491)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190401(CHEMBL211177 | tert-butyl-(3S)-3-{[(5R)-5-(2,2,2-t...)
Affinity DataIC50:  5nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190407((3S)-3-methylpentan-3-yl 3-(5-(1,1,1,3,3,3-hexaflu...)
Affinity DataIC50:  5nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386885(CANAGLIFLOZIN | CANAGLIFLOZIN HYDRATE | US10752604...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190397(CHEMBL208825 | tert-butyl-(3S)-3-{[5-(2,2,2-triflu...)
Affinity DataIC50:  7nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190399(3-{[5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl...)
Affinity DataIC50:  7nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396778(CHEMBL2172492)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190410(CHEMBL378459 | tert-butyl-(3R)-3-{[(5R)-5-(2,2,2-t...)
Affinity DataIC50:  8nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386886(CHEMBL2048488)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386883(CHEMBL2048496)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190408(3-{[5-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl...)
Affinity DataIC50:  9nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50186046(CHEMBL210138 | N-(4-cyanobenzyl)-N-(5-(1,1,1,3,3,3...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396781(CHEMBL2172389)
Affinity DataIC50:  9.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50303241((1S,3'R,4'S,5'S,6'R)-6-(4-ethoxybenzyl)-6'-(hydrox...)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386889(CHEMBL2048493)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190413(CHEMBL379321 | tert-butyl-(3R)-3-{[5-(2,2,2-triflu...)
Affinity DataIC50:  10nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386884(CHEMBL2048497)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386880(CHEMBL2048487)
Affinity DataIC50:  11nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50186054(4-((3,5-dichloro-N-(5-(1,1,1,3,3,3-hexafluoro-2-hy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50351435(CHEMBL1819489)
Affinity DataIC50:  11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386881(CHEMBL2048490)
Affinity DataIC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386888(CHEMBL2048491)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396771(CHEMBL2172383)
Affinity DataIC50:  14.2nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396770(CHEMBL2172384)
Affinity DataIC50:  14.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190415(5-methyl-(3S)-3-{[5-(2,2,2-trifluoro-1-hydroxy-1-t...)
Affinity DataIC50:  15nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM20875(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)
Affinity DataIC50:  16.4nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50396773(CHEMBL2172381)
Affinity DataIC50:  16.8nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50190416(CHEMBL378896 | N-(3-(diisopropylamino)-3-oxopropyl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of malonyl-coenzyme A decarboxylaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50386882(CHEMBL2048492)
Affinity DataIC50:  19nMAssay Description:Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Chugai Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50351439(CHEMBL1819492)
Affinity DataIC50:  19nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50186053(CHEMBL385355 | N-(5-(1,1,1,3,3,3-hexafluoro-2-hydr...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50186052(CHEMBL210190 | N-(4-cyanobenzyl)-N-(5-(1,1,1,3,3,3...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMalonyl-CoA decarboxylase, mitochondrial(Homo sapiens (Human))
Chugai Pharma Usa

Curated by ChEMBL
LigandPNGBDBM50186047(CHEMBL209430 | N-ethyl-N-(6-(1,1,1,3,3,3-hexafluor...)
Affinity DataIC50:  22nMAssay Description:Inhibition of MCDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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