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Found 3282 with Last Name = 'zeng' and Initial = 'q'
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441652(CHEMBL2437433)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441649(CHEMBL2437416)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441646(CHEMBL2437421)
Affinity DataKi:  0.700nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441637(CHEMBL2437430)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441647(CHEMBL2437420)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441642(CHEMBL2437425)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441641(CHEMBL2437426)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441645(CHEMBL2437422)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441654(CHEMBL2437431)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441638(CHEMBL2437429)
Affinity DataKi:  2.80nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441644(CHEMBL2437423)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441653(CHEMBL2437432)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441651(CHEMBL2437417)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441640(CHEMBL2437427)
Affinity DataKi:  5.10nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441655(CHEMBL2437415)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441643(CHEMBL2437424)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441656(CHEMBL2437414)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441639(CHEMBL2437428)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441650(CHEMBL2437418)
Affinity DataKi:  77nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50441648(CHEMBL2437419)
Affinity DataKi:  420nMAssay Description:Displacement of [3H]-N-alpha-methyl histamine from histamine H3 receptor in guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474287(2-((3-(difluoromethoxy)pyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474223(2-(2,6-difluorobenzyl)-8-(2-(dimethylamino) pyridi...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474223(2-(2,6-difluorobenzyl)-8-(2-(dimethylamino) pyridi...)
Affinity DataIC50:  0.100nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50:  0.100nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474315(7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyrid...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474337(7-(azetidin-l-yl)-2-(2,6-difluorobenzyl)-8-(3-met ...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM474233(5-[5-amino-7-(4-fluorophenyl)-2-[(3-fluoropyrid in...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474316(7-(4-fluorophenyl)-8-(3-methylimidazo[l,2-a] pyrid...)
Affinity DataIC50:  0.100nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474330(7-(4-fluoro-1H-pyrazol-1-yl)-2-((3-fluoropyridin- ...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474334(2-(2,6-difluorobenzyl)-8-(3-methylimidazo[l,2-a] p...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474281(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of EGFR exon19 deletion mutant (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474329(7-(3-fluoro-1H-pyrazol-1-yl)-2-((3-fluoropyridin- ...)
Affinity DataIC50:  0.200nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474329(7-(3-fluoro-1H-pyrazol-1-yl)-2-((3-fluoropyridin- ...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474328(7-(4-fluorophenyl)-2-(2-methoxyethyl)-8-(3-met hyl...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474318(8-(3-methylimidazo[l,2-a]pyridin-6-yl)-7-(oxazo l-...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Dizal (Jiangsu) Pharmaceutical

US Patent
LigandPNGBDBM474222(5-(5-amino-2-(2,6-difluorobenzyl)-7-(4- fluorophen...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337251((S)-5-chloro-6-(4-(1-(4-chloro-2-fluorobenzyl)pipe...)
Affinity DataIC50:  0.200nMAssay Description:Binding affinity to human CXCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474223(2-(2,6-difluorobenzyl)-8-(2-(dimethylamino) pyridi...)
Affinity DataIC50:  0.200nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337251((S)-5-chloro-6-(4-(1-(4-chloro-2-fluorobenzyl)pipe...)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at human CXCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50347672(CHEMBL1802904)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50446659(CHEMBL3116468)
Affinity DataIC50:  0.300nMAssay Description:Binding affinity to human CXCR3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474284(7-(4-fluorophenyl)-2-((3-fluoropyridin-2-yl) methy...)
Affinity DataIC50:  0.300nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474335((S)-7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] p...)
Affinity DataIC50:  0.300nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50123453(CHEMBL3623290)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of EGFR (unknown origin) by HTRF assay in presence of Km of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337250((S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-y...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at human CXCR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50337250((S)-5-chloro-6-(4-(1-(4-chlorobenzyl)piperidin-4-y...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of [125I]CXCL10 from human CXCR3 expressed in mouse BA/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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