TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Indiana State University
Curated by ChEMBL
Indiana State University
Curated by ChEMBL
Affinity DataKi: 0.0330nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.0520nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.0730nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.170nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.200nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.206nM ΔG°: -57.5kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-4(Homo sapiens (Human))
Indiana State University
Curated by ChEMBL
Indiana State University
Curated by ChEMBL
Affinity DataKi: 0.220nMAssay Description:Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Indiana State University
Curated by ChEMBL
Indiana State University
Curated by ChEMBL
Affinity DataKi: 0.270nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.280nM ΔG°: -56.7kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.290nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.340nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Indiana State University
Curated by ChEMBL
Indiana State University
Curated by ChEMBL
Affinity DataKi: 0.350nMAssay Description:Displacement of [3H]epibatidine from alpha4beta2 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...More data for this Ligand-Target Pair
Affinity DataKi: 0.470nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.514nM ΔG°: -55.2kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 0.530nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.540nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.550nM ΔG°: -55.0kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetProkineticin receptor 1(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.560nM ΔG°: -54.9kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.570nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.580nMAssay Description:Binding affinity towards Opioid receptor delta 1 from guinea pig brain using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.620nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.640nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.670nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.680nM ΔG°: -54.4kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 0.690nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.710nM ΔG°: -54.3kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.720nM ΔG°: -54.3kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.810nM ΔG°: -54.0kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 0.810nMAssay Description:Displacement of [3H]CP55940 from cloned human CB2 receptorMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.890nM ΔG°: -53.7kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Binding affinity towards Opioid receptor mu 1 from guinea pig brain using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.930nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.930nM ΔG°: -53.6kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
Affinity DataKi: 1nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Affinity DataKi: 1nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Affinity DataKi: 1nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
Affinity DataKi: 1nM IC50: <10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]CP55940 from cloned human CB2 receptorMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Rensselaer Polytechnic Institute
Curated by ChEMBL
Rensselaer Polytechnic Institute
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Binding affinity towards Opioid receptor kappa 1 from guinea pig brain using [3H]U69,593 as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assayMore data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 1.03nM ΔG°: -53.4kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair
TargetProkineticin receptor 2(Cricetulus griseus (Chinese hamster))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 1.06nM ΔG°: -53.3kJ/moleT: 2°CAssay Description:An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...More data for this Ligand-Target Pair