TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.90nMAssay Description:Binding affinity to human P2X7R assessed as inhibition constantMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 2.90nMAssay Description:Binding affinity to human MAO-B assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Binding affinity to human CB2R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 8nMAssay Description:Binding affinity to CSF1R (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 9nMAssay Description:Binding affinity to GSK-3 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Binding affinity to human CB2R assessed as inhibition constantMore data for this Ligand-Target Pair
TargetMelatonin receptor type 1A(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 90nMAssay Description:Binding affinity to human melatonin MT1 assessed as inhibition constantMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 250nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 970nMAssay Description:Reversible inhibition of MAO-B in Wistar rat assessed as inhibition constant followed by using clorgyline as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 1.10E+3nMAssay Description:Binding affinity to human CB1R assessed as inhibition constant and incubated for 90 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of GSK-3 (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Binding affinity to recombinant human S1PR1 expressed in cell membraneMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 2.10nMAssay Description:Inhibition of recombinant human GSK-3betaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production preincubated for 30 mins before LPS challenge ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to MERTK (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at TLR4 in human PBMC assessed as inhibition of LPS-stimulated TNFalpha production preincubated for 30 mins before LPS challenge ...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human P2Y12More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 6.70nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human P2X7RMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 8.70nMAssay Description:Inhibition of sEH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair