TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.0170nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.0620nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.106nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.110nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.120nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.127nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.150nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.230nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.260nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.300nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.350nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.360nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor in humansMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.360nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.380nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.410nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.410nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Displacement of [3H]cyanoimipramine from SERT in rat cerebral cortex homogenateMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.460nMAssay Description:Affinity for Serotonin transporter by displacing [3H]-Paroxetine from rat forebrainMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.480nMAssay Description:Binding affinity to dopamine transporter in membranes of cells selectively expressing the human genes for DATMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.5nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 0.510nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
Affinity DataKi: 0.610nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.640nMAssay Description:Binding affinity to dopamine transporter (DAT) in rat forebrain tissueMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.690nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudateputamen tissue from rat brainMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Affinity for Serotonin transporter by displacing [3H]-Paroxetine from rat forebrainMore data for this Ligand-Target Pair
Affinity DataKi: 0.840nMAssay Description:Displacement of [3H]nisoxetine from NET in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataKi: 0.910nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 0.930nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.960nMAssay Description:Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamenMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.960nMAssay Description:Displacement of [3H]-GBR-12,935 from rat forebrain Dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 0.960nMAssay Description:Displacement of [3H]beta-CIT from DAT in rat caudate homogenateMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Institute For Neurodegenerative Disorders
Curated by ChEMBL
Affinity DataKi: 1.06nMAssay Description:Displacement of [3H]methoxy-PEPY from rat mGluR5 expressed in human HEK-293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 1.13nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
Affinity DataKi: 1.15nMAssay Description:Tested on genetically transfected COS7 cell membranes selectively expressing human 5-hydroxytryptamine 2A receptor, using [3H]-ketanserin as radiolig...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Binding affinity for dopamine transporters in rat brain tissue.More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Binding affinity to serotonin transporter (SERT) in membranes of cells selectively expressing the human genes for SERTMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Binding affinity (Ki) at Dopamine receptor D2 using rat caudate cells with nemonapride (0.075 nM) as a radioligand and 10 M haloperidol as a blank ag...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Binding affinity to dopamine transporter (DAT) in rat forebrain tissueMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Binding affinity to serotonin transporter (SERT) in rat forebrain tissueMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Affinity for Serotonin transporter by displacing [3H]-Paroxetine from rat forebrainMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Yale School Of Medicine
Curated by ChEMBL
Yale School Of Medicine
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Binding affinity for dopamine transporters in rat brain tissue.More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 1.56nMAssay Description:Displacement of [3H]paroxetine from SERT in rat frontoparietal cerebral cortexMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortexMore data for this Ligand-Target Pair