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Found 430 with Last Name = 'bussiere' and Initial = 'd'
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185219((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(quinu...)
Affinity DataIC50:  0.320nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185221((S)-3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(quinu...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185218((S)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(pyrro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50313013(CHEMBL1080901 | CT-98024 | N2-(2-(4-(2,4-dichlorop...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FGFR3 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of recombinant FGFR1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181308(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185217(3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(piperidin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant FGFR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185224(3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(piperidin...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant FGFR2More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FGFR3-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181319(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2nMAssay Description:Inhibition of FGFR2 juxtamembrane domain-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
LigandPNGBDBM50380371(CHEMBL2017970)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380366(CHEMBL2017965)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380369(CHEMBL2017968)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of FGFR1-mediated proliferation of mouse BAF3 cells transformed with TEL-Kinase constructMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181308(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181313(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185220(3-(1H-benzo[d]imidazol-2-yl)-6-methyl-4-(piperidin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185216(3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(piperidin...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181313(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181311(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181308(4-amino-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]i...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181319(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380367(CHEMBL2017966)
Affinity DataIC50:  4.10nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of wild type FGFR1 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50355393(BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of wild type FGFR2 expressed in HEK293 cells assessed as inhibition of autophosphorylation of tyrosine residue after 40 mins by ELISA assa...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181303(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Affinity DataIC50:  6nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50243389(CHEMBL3185148)
Affinity DataIC50:  7nMAssay Description:Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185226((R)-3-(1H-benzo[d]imidazol-2-yl)-6-chloro-4-(pyrro...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380370(CHEMBL2017969)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50185215((S)-3-(1H-benzo[d]imidazol-2-yl)-4-(quinuclidin-3-...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380372(CHEMBL2016592)
Affinity DataIC50:  8nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181312(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181320(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181319(4-amino-3-(6-morpholino-1H-benzo[d]imidazol-2-yl)-...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181315(4-amino-3-(5-(4-methylpiperazin-1-yl)-3H-imidazo[4...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50181313(4-amino-3-(1H-benzo[d]imidazol-2-yl)-1,7-naphthyri...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against FGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181320(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181312(4-amino-3-(5-morpholino-3H-imidazo[4,5-b]pyridin-2...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50305245((+/-)-3-amino-1-(6-ethyl-1-(3-hydroxyphenyl)-3,4-d...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EG5 after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chiron

Curated by ChEMBL
LigandPNGBDBM50181311(4-Amino-3-(6-morpholin-4-ylbenzimidazol-2-yl)hydro...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against VEGFR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181303(4-amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naph...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Chiron

Curated by ChEMBL
LigandPNGBDBM50181320(4-Amino-3-[6-(4-methylpiperazinyl)benzimidazol-2-y...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity against VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50380377(CHEMBL2017977 | WO2007/084786, Compound 85)
Affinity DataIC50:  14nMAssay Description:Inhibition of PI3Kalpha using 1-alpha-phosphotidylinositol as substrate by ATP depletion assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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