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Found 9 Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 beta' and Ligand = 'BDBM50325983'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  2nMAssay Description:A selection of compounds was screened against a selected panel of kinases based on single point inhibitory ability to determine absolute inhibitory a...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of from NanoLuc-fused GSK-3-beta (unknown origin) transfected in HEK293 cells using tracer K8 incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human GSK3beta using biotin-CREB peptide substrate after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  7nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of human recombinant GSK3beta using GSK3 peptide as substrate preincubated for 15 mins followed by ATP addition and measured after 90 mins...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  30nMAssay Description:Inhibition of GSK3-betaMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant GSK3-beta after 1 hr by KinaseGlo luciferase assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM50325983(6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidaz...)
Affinity DataEC50:  1.50E+3nMAssay Description:Inhibition of GSK3-beta in human HepG2 cells assessed as incorporation of [3H]glucose into glycogen after 3 hrs by liquid scintillation countingMore data for this Ligand-Target Pair