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Found 345 with Last Name = 'clos' and Initial = 'mv'
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50200340((+/-)-huprine Y-HCl | (+/-)-huprineY hydrochloride...)
Affinity DataKi:  0.0330nMAssay Description:Binding affinity to human AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379268(CHEMBL3216556)
Affinity DataKi:  1.5nMAssay Description:Competitive inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50007801(CHEMBL3233832)
Affinity DataKi:  2.70nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate assessed as dissociation constant for enzyme-inhibitor complex by Li...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50007801(CHEMBL3233832)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate assessed as dissociation constant for enzyme-substrate-inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50049862(CHEMBL3322232)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271142(6-Chloro-9-[(3-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)...)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50271142(6-Chloro-9-[(3-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)...)
Affinity DataIC50:  0.270nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10590(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.290nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271140(9-[(3-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]pi...)
Affinity DataIC50:  0.290nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10590(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10586(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.320nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10588(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{7-[(6-...)
Affinity DataIC50:  0.330nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10585(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(1,...)
Affinity DataIC50:  0.330nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10584(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{7-[(1,...)
Affinity DataIC50:  0.340nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10589(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(6-...)
Affinity DataIC50:  0.400nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10586(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{3-{N-{...)
Affinity DataIC50:  0.420nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379273(CHEMBL1994202 | US9238626, (-)-Huprine Y HCl)
Affinity DataIC50:  0.430nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10587(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(6-...)
Affinity DataIC50:  0.450nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10583(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(1,...)
Affinity DataIC50:  0.5nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271141(6-Chloro-9-[(2-{4-[(5,6-dimethoxy-1-oxoindan-2-yl)...)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM9063(5,6-Dimethoxy-2-{[7-(1,2,3,4-tetrahydro-acridin-9-...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human serum BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50:  0.610nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50271141(6-Chloro-9-[(2-{4-[(5,6-dimethoxy-1-oxoindan-2-yl)...)
Affinity DataIC50:  0.670nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50200340((+/-)-huprine Y-HCl | (+/-)-huprineY hydrochloride...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins before substrate addition by Ellman methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50379273(CHEMBL1994202 | US9238626, (-)-Huprine Y HCl)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10587(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(6-...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50200340((+/-)-huprine Y-HCl | (+/-)-huprineY hydrochloride...)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human erythrocyte AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50:  0.780nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271190(9-[(3-{4-[(5,6-dimethoxyindan-2-yl)methyl]piperidi...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271192(6-Chloro-9-[(3-{4-[(5,6-dimethoxyindan-2-yl)methyl...)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10582(15-ethyl-N-[8-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  0.820nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50271140(9-[(3-{4-[(5,6-Dimethoxy-1-oxoindan-2-yl)methyl]pi...)
Affinity DataIC50:  0.880nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10583(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{6-[(1,...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50271192(6-Chloro-9-[(3-{4-[(5,6-dimethoxyindan-2-yl)methyl...)
Affinity DataIC50:  1.06nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10592(7-chloro-15-methyl-10-azatetracyclo[11.3.1.0^{2,11...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50007795(CHEMBL3233826)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50200334((-)-(7S,11S)-huprine H3)
Affinity DataIC50:  1.15nMAssay Description:Inhibition of bovine erythrocyte AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10589(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(6-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50200343((-)-(7S,11S)-huprine H7)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of bovine erythrocyte AChEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10585(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{8-[(1,...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50108994(CHEMBL3600555)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50007796(CHEMBL3233827)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50377921(SODIUM NITROPRUSSIDE)
Affinity DataIC50:  1.74nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271191(6-Chloro-9-[(2-{4-[(5,6-dimethoxyindan-2-yl)methyl...)
Affinity DataIC50:  1.86nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50108990(CHEMBL3600551)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM10584(3-Chloro-6,7,10,11-tetrahydro-9-methyl-12-{{7-[(1,...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50049859(CHEMBL3322231)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL
LigandPNGBDBM50271190(9-[(3-{4-[(5,6-dimethoxyindan-2-yl)methyl]piperidi...)
Affinity DataIC50:  2.16nMAssay Description:Inhibition of human erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic)

Curated by ChEMBL
LigandPNGBDBM50271189(9-[(2-{4-[(5,6-Dimethoxyindan-2-yl)methyl]piperidi...)
Affinity DataIC50:  2.28nMAssay Description:Inhibition of bovine erythrocyte AChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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