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Found 41 with Last Name = 'coenen' and Initial = 'h'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  0.0130nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119550(5-Chloro-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  0.0500nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.0970nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(BOVINE)
Forschungszentrum JüLich

Curated by ChEMBL
LigandPNGBDBM50062852(8-Cyclopentyl-3-(3-fluoro-propyl)-1-propyl-3,7-dih...)
Affinity DataKi:  0.180nMAssay Description:In vitro binding affinity for Adenosine A1 receptor of bovine cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50091095(2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-methoxy...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119548(2-(2-Dimethylaminomethyl-phenylsulfanyl)-5-fluorom...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50091097(3-Amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-b...)
Affinity DataKi:  1.10nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073437(CHEMBL113382 | [5-Chloro-2-(2-dimethylaminomethyl-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of 5-HT reuptake (SERT) in rat brain synaptosomes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119549(2-(5-Amino-4-chloro-2-nitro-phenylsulfanyl)-N,N-di...)
Affinity DataKi:  2.39nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50073805(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to dopamine D4 receptor in Wistar rat brain slicesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119551(CHEMBL142517 | [2-(4-Chloro-5-fluoro-2-nitro-pheny...)
Affinity DataKi:  4.16nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by SERT binding assay by using [125I]-IDAM as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50073437(CHEMBL113382 | [5-Chloro-2-(2-dimethylaminomethyl-...)
Affinity DataKi:  55nMAssay Description:Selectivity of the compound for norepinephrine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119550(5-Chloro-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  650nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Norepinephrin transpoter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  699nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50110577(2-(2-((dimethylamino)methyl)phenylthio)-5-iodoanil...)
Affinity DataKi:  840nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Norepinephrin transpoter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(PIG)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358840(CHEMBL1923415)
Affinity DataKi:  2.30E+3nMAssay Description:Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119551(CHEMBL142517 | [2-(4-Chloro-5-fluoro-2-nitro-pheny...)
Affinity DataKi:  2.81E+3nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Norepinephrin transpoter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119550(5-Chloro-2-(2-dimethylaminomethyl-phenylsulfanyl)-...)
Affinity DataKi:  3.02E+3nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119549(2-(5-Amino-4-chloro-2-nitro-phenylsulfanyl)-N,N-di...)
Affinity DataKi:  3.05E+3nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358838(CHEMBL1923292)
Affinity DataKi:  3.90E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358840(CHEMBL1923415)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(PIG)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358839(CHEMBL1923293)
Affinity DataKi:  4.20E+3nMAssay Description:Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358838(CHEMBL1923292)
Affinity DataKi:  5.70E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(PIG)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358841(CHEMBL1923416)
Affinity DataKi:  5.80E+3nMAssay Description:Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358839(CHEMBL1923293)
Affinity DataKi:  5.90E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358840(CHEMBL1923415)
Affinity DataKi:  6.10E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(PIG)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358838(CHEMBL1923292)
Affinity DataKi:  7.00E+3nMAssay Description:Displacement of [3H]ketanserin from 5-HT2 receptor in porcine cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358838(CHEMBL1923292)
Affinity DataKi:  7.60E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358840(CHEMBL1923415)
Affinity DataKi:  9.00E+3nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358840(CHEMBL1923415)
Affinity DataKi:  1.50E+4nMAssay Description:Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119549(2-(5-Amino-4-chloro-2-nitro-phenylsulfanyl)-N,N-di...)
Affinity DataKi:  1.51E+4nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Norepinephrin transpoter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358839(CHEMBL1923293)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358839(CHEMBL1923293)
Affinity DataKi:  1.70E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358841(CHEMBL1923416)
Affinity DataKi:  1.70E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358838(CHEMBL1923292)
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358839(CHEMBL1923293)
Affinity DataKi:  2.30E+4nMAssay Description:Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358841(CHEMBL1923416)
Affinity DataKi:  2.90E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2long receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
University Of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50119551(CHEMBL142517 | [2-(4-Chloro-5-fluoro-2-nitro-pheny...)
Affinity DataKi:  3.19E+4nMAssay Description:In vitro binding affinity of the compound in LLC-PK1 cells by Dopamine transporter binding assay by using [125I]-IPT as a radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Sus scrofa)
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358841(CHEMBL1923416)
Affinity DataKi:  3.50E+4nMAssay Description:Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Forschungszentrum J£Lich

Curated by ChEMBL
LigandPNGBDBM50358841(CHEMBL1923416)
Affinity DataKi:  4.50E+4nMAssay Description:Displacement of [3H]spiperone from human dopamine D2short receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed