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Found 126 with Last Name = 'comess' and Initial = 'km'
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.400nM ΔG°:  -53.6kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223986((3R,4S)-1-[(1S)-7-fluoroindan-1-yl]-N,N-dimethyl-4...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223985(rac-(3R,4S)-1-(2-fluoro-6-methylbenzyl)-N,N-dimeth...)
Affinity DataKi:  4nM ΔG°:  -47.9kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223984(rac-(3R,4S)-1-(2-methoxybenzyl)-N,N-dimethyl-4-(1-...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.8kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223989(A-395N (6))
Affinity DataKi:  1.83E+3nM ΔG°:  -32.7kJ/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446181(CHEMBL3108912 | US9518026, Example 1 | US9956214, ...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446180(CHEMBL3108998 | US9518026, Example 25 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446177(CHEMBL3108991 | US9518026, Example 18 | US9956214,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446178(CHEMBL3108913 | US9518026, Example 3 | US9956214, ...)
Affinity DataIC50:  4nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446176(CHEMBL3108996 | US9518026, Example 23 | US9956214,...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446175(CHEMBL3108986 | US9518026, Example 13 | US9956214,...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446174(CHEMBL3109010 | US9518026, Example 38 | US9956214,...)
Affinity DataIC50:  6nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446171(CHEMBL3108999 | US9518026, Example 26 | US9956214,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446172(CHEMBL3108997 | US9518026, Example 24 | US9956214,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446173(CHEMBL3108988 | US9518026, Example 15 | US9956214,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataIC50:  7.51nMpH: 7.5 T: 2°CAssay Description:For the assay, compounds or nonbiotinylated H3(23-34) peptide were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446169(CHEMBL3108987 | US9518026, Example 14 | US9956214,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446170(CHEMBL3108985 | US9518026, Example 12 | US9956214,...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17478(2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446168(CHEMBL3109009 | US9518026, Example 37 | US9956214,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17607(2-[(4-fluorobenzene)sulfonamido]-5,6,7,8-tetrahydr...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446165(CHEMBL3108992 | US9518026, Example 19 | US9956214,...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446167(CHEMBL3108916 | US9518026, Example 8 | US9956214, ...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446166(CHEMBL3108990 | US9518026, Example 17 | US9956214,...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446164(CHEMBL3108995 | US9518026, Example 22 | US9956214,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17604(2-[(4-fluorobenzene)sulfonamido]naphthalene-1-carb...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446163(CHEMBL3109002)
Affinity DataIC50:  17nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223987(A-395 (5) | rac-(3R,4S)-1-(7-fluoro-2,3-dihydro-1H...)
Affinity DataIC50:  18nMT: 2°CAssay Description:IC50 values were determined for compounds A-395 and A-395N at 75 nM of EZH2 trimeric complex (EZH2-EED-SUZ12), 3 μM of human nucleosome and 1 &#...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17603(2-benzenesulfonamidonaphthalene-1-carboxylic acid ...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17606(2-[(4-fluorobenzene)sulfonamido]-8-methyl-5,6-dihy...)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase KMT5B(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223981(6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthala...)
Affinity DataIC50:  25nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446162(CHEMBL3108993 | US9518026, Example 20 | US9956214,...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17608((8S)-2-[(4-fluorobenzene)sulfonamido]-8-methyl-5,6...)
Affinity DataIC50:  27nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataIC50:  29nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446160(CHEMBL3109006 | US9518026, Example 34 | US9956214,...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446161(CHEMBL3109003 | US9518026, Example 30 | US9956214,...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446158(CHEMBL3108917 | US9518026, Example 10 | US9956214,...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446159(CHEMBL3108915 | US9518026, Example 6 | US9956214, ...)
Affinity DataIC50:  35nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446157(CHEMBL3108994 | US9518026, Example 21 | US9956214,...)
Affinity DataIC50:  39nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446156(CHEMBL3109001)
Affinity DataIC50:  40nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446155(CHEMBL3109007 | US9518026, Example 35 | US9956214,...)
Affinity DataIC50:  49nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446154(CHEMBL3108989 | US9518026, Example 16 | US9956214,...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataIC50:  71nMAssay Description:Inhibition of probe-5 binding to human TNFalpha (77 to 233 residues) at 1 nM by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University Of Washington

Curated by ChEMBL
LigandPNGBDBM50446153(CHEMBL3108984 | US9518026, Example 11 | US9956214,...)
Affinity DataIC50:  81nMAssay Description:Inhibition of Toxoplasma gondii CDPK1 using PLARTLSVAGLPGKK-OH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM17600(2-benzenesulfonamido-5-ethylbenzoic acid | sulfona...)
Affinity DataIC50:  90nMpH: 7.4 T: 2°CAssay Description:A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Mus musculus)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566088(CHEMBL4793924)
Affinity DataIC50:  99nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Mus musculus)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566087(CHEMBL4787790)
Affinity DataIC50:  119nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTumor necrosis factor(Mus musculus)
Abbvie

Curated by ChEMBL
LigandPNGBDBM50566082(CHEMBL4779359)
Affinity DataIC50:  128nMAssay Description:Inhibition of TNFalpha in mouse L929 cells exposed to compound incubated for 1 hr with mouse TNFalpha by luminescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
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